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Theophylline dosage

Final dose: Adjust to maintain peak serum steady state theophylline between 5 to 10 mcg/mL in neonates and between 10 to 15 mcg/mL in older infants. Children 1 year and older without risk factors for impaired clearance: -Weight under 45 kg: Initial dose: 12 to 14 mg/kg/day (max 300 mg) given as evenly divided doses every 4 to 6 hours At first, the dose is 12 to 14 milligrams (mg) per kg of body weight per day as a single dose, usually in the morning, or divided and given two times per day. Your doctor may adjust your dose as needed. However, the total dose is usually not more than 20 mg per kg of body weight per day or 600 mg per day Use ideal body weight to calculate dose 1 mg/kg results in 2 mg/L (34.4 mmol/L) increase in serum theophylline Therapeutic range: 10-20 mg/L (172-344 mmol/L There have been clinical reports suggesting dose-dependent elimination of theophylline in some patients, especially at the higher end of the therapeutic range and most obviously at concentrations greater than 20 mg/l. For these patients, small increases in doses may result in dramatic increases in serum concentrations

Theophylline Dosage Guide + Max Dose, Adjustments - Drugs

Theophylline is a prescription drug. It's available as an oral solution, an extended-release tablet, and an extended-release capsule. It's also available in an intravenous (IV) form, which is. 4.6 mg/kg IV loading dose infused over 30 minutes in a patient who has received no theophylline in the previous 24 hours will produce an average peak serum theophylline concentration of 10 mcg/mL (range 6 to 16 mcg/mL); calculate mg/kg dose based on ideal body weight How should this medicine be used? Theophylline comes as an extended-release (long-acting) tablet, extended-release capsule, and a solution (liquid) to take by mouth. It usually is taken every 6, 8, 12, or 24 hours

Theophylline (Oral Route) Proper Use - Mayo Clini

Theo 24, Theocron (theophylline) dosing, indications

Theophylline side effects. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.. Call your doctor at once if you have: severe or continued vomiting;. ongoing headache, trouble sleeping;. rapid heartbeats A single 5 mg/kg dose of theophylline, in a patient who has not received any theophylline in the previous 24 hours, will produce an average peak serum theophylline concentration of 10 mcg/mL (range 5-15 mcg/mL) In children 6-15 years of age, the final theophylline dose should not exceed 16 mg/kg/day up to a maximum of 400 mg/day in the presence of risk factors for reduced theophylline clearance or if it is not feasible to monitor serum theophylline concentrations Absorption. Theophylline (anhydrous) extended-release tablets administered in the fed state is completely absorbed after oral administration. In a single-dose crossover study, two 400 mg theophylline (anhydrous) extended-release tablets were administered to 19 normal volunteers in the morning or evening immediately following the same standardized meal (769 calories consisting of 97 grams. Theophylline is used off label to treat cough caused by bronchoconstriction. It is given by mouth in the form of a tablet or liquid, or in hospital as an injection. The most common side effects include stomach upset and excitement. It should be used with caution in pets with abnormal heart rhythms, seizures, stomach ulcers, hyperthyroidism, kidney, liver, or heart disease, severely high blood.

Theophylline dosing review - RxKinetic

Dosage and Administration of Theophylline Theophylline should be administered 2 to 3 times a day and the suggested dosage for dogs is 2.25 to 5 grams of medication per pound of weight of the pet. The medication should be administered on an empty stomach and food should be given an hour after the administration of the medication Sometimes the doctor will start at ¼ or ½ the dose and increase to a full dose over 2-3 weeks. This is designed to allow you to become used to the medicine, and it helps reduce the number of side effects. Question: What conditions influence the theophylline dose I need? Answer: The dose of theophylline varies from person to person and. Theophylline is rapidly and completely absorbed after oral administration in solution or immediate-release solid oral dosage form. After a single immediate-release dose of 5 mg/kg in adults, a mean peak serum concentration of about 10 mcg/mL (range 5 - 15 mcg/mL) can be expected 1 - 2 hr after dose. Co-administration of theophylline with foo If theophylline is to be given orally, the dose given in Table 22-4 (in mg/kg/h) must be multiplied by the appropriate dosage interval for the dosage form being used: D = (theophylline dose • Wt • τ)/S, where Wt is patient weight, τ is the dosage interval, and S is the appropriate salt form correction factor for aminophylline or. Adverse reactions associated with theophylline are generally mild when peak serum theophylline concentrations are <20 mcg/mL and mainly consist of transient caffeine-like adverse effects such as..

Smoking -Drug interactions

The dosage is based on your medical condition, response to treatment, age, weight, lab tests (theophylline blood levels), and other medications you may be taking Theophylline is a dimethylxanthine having the two methyl groups located at positions 1 and 3. It is structurally similar to caffeine and is found in green and black tea. It has a role as a vasodilator agent, a bronchodilator agent, a muscle relaxant, an EC 3.1.4.* (phosphoric diester hydrolase) inhibitor, an anti-asthmatic drug, an anti-inflammatory agent, an immunomodulator, an adenosine.

Theophylline Side Effects, Dosage, Uses & Mor

In most individuals, a plasma-theophylline concentration of 10-20 mg/litre (55-110 micromol/litre) is required for satisfactory bronchodilation, although a lower plasma-theophylline concentration of 5-15 mg/litre may be effective diarrhea. difficulty in passing urine (dribbling) dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position. dry mouth. fast, pounding, or irregular heartbeat or pulse. fever. increased thirst. irregular heartbeat. loss of appetite Dosage requirement must be guided by the patient's serum theophylline concentrations, safety, and tolerability (refer to detailed product guideline). Child: Individualise dosing based on serum theophylline levels; use ideal body weight to calculate dose. As theophylline monohydrate modified-release tab: ≥6 years Usual maintenance dose: 9 mg.

Theophylline Extended-Release Tablets (100 mg, 200 mg, 300

Dose: 0.2 mg/kg/h IV; Start: load 5 mg/kg/dose IV x1 if no theophylline w/in 24h; Info: not recommended per NIH guidelines; adjust dose based on serum levels; reduced clearance risk factors include hepatic impairment, CHF, fever, sepsis w/ multi-organ failure, shock, and hypothyroidism Adjust dosage carefully Theophylline has a relatively long half-life in certain patient populations (the elderly and CHF patients), consequently it may take several days to reach steady state. Dosage increases should be made with caution. The patient must be followed closely for signs of toxicity Pharmacokinetics: Overview Theophylline is rapidly and completely absorbed after oral administration in solution or immediate-release solid oral dosage form. Theophylline does not undergo any appreciable pre-systemic elimination, distributes freely into fat-free tissues and is extensively metabolized in the liver

Dosage adjustment based on serum theophylline concentrations: Infants, Children, and Adolescents: Note: Recheck serum theophylline concentrations after 3 days when using oral dosing, or after 12 hours (children) or 24 hours (adults) when dosing intravenously. Patients maintained with oral therapy should be reassessed at 6- to 12-month intervals. Administration of the median theophylline dose required to achieve a therapeutic serum theophylline concentration in a given population may result in either sub-therapeutic or potentially toxic serum theophylline concentrations in individual patients. For example, at a dose of 900 mg/d in adults < 60 years or 22 mg/kg/d in children 1-9 years. If used, the maintenance dose must be conservative and in accord with the following guidelines: Initial Maintenance Dosage of Theophylline, Anhydrous. Premature Infants: Up to 24 days postnatal age - 1.0 mg/kg q12h. Beyond 24 days postnatal age - 1.5 mg/kg ql2h. Infants 6 to 52 weeks The molecular formula of anhydrous theophylline is C 7 H 8 N 4 O 2 with a molecular weight of 180.17.. Theo-24 (theophylline anhydrous capsule) ® is available as capsules intended for oral administration, containing 100 mg, 200 mg, 300 mg, or 400 mg of anhydrous theophylline per capsule, in an extended-release formulation which allows a 24-hour dosing interval for appropriate patients Theophylline(Aquaphyllin) generic is a bronchodilator, prescribed for asthma, chronic bronchitis, emphysema, and other lung diseases. It works by relaxing the muscle around the airways in the lungs

Aminophylline - Xanthines - Medical Brand Names

The present study is a prospective evaluation of a dosing nomogram for oral theophylline in 69 middle-aged and elderly patients (mean age 58.5 +/- 15.4 years) with obstructive lung disease. The main features of the nomogram were that the theophylline dose was increased in middle-aged as compared to Theophylline is especially useful in prevention and treatment of asthmatic symptoms. Levels in blood are monitored to assure therapeutic dosage. Sampling times. for Neonates: 2 hours after the first loading dose to calculate the volume of distibution (Vd). Every 4-7 days to calculate clearance and dosage adjustment. for Infants ¶ Dose reduction and/or serum theophylline concentration measurement is indicated whenever adverse effects are present, physiologic abnormalities that can reduce theophylline clearance occur (e.g., sustained fever), or a drug that interacts with theophylline is added or discontinued (see package insert for warnings dose-dependency of theophylline metabolism in patients a priori is not possible, but patients with very high initial clearance rates (i.e., low steady state serum theophylline concentrations at above average doses) have the greatest likelihood of experiencing large changes in serum theophylline concentration in response to dosage changes In view of the large interindividual differences in theophylline clearance and the narrow therapeutic range it is essential to individualize the theophylline dose. In order to do so, estimation of minimum and maximum serum theophylline concentrations during one dosing interval from one or two blood

Theophylline is prescribed for bronchial asthma, for chronic obstructive pulmonary disease, and for newborn apnea. The drug is extensively metabolized 1 with peak serum levels reached four hours after oral dose. Troleandomycin and erythromycin may slow theophylline elimination Administration of the median theophylline dose required to achieve a therapeutic serum theophylline concentration in a given population may result in either sub-therapeutic or potentially toxic serum theophylline concentrations in individual patients. For example, at a dose of 900 mg/d in adults < 60 years or 22 mg/kg/d in children 1 to 9 years. Theophylline is a prescription medication used to treat chronic (ongoing) lung diseases such as asthma, emphysema, and chronic bronchitis. This medication belongs to a group of drugs called methylxanthines

Dosage and Administration of Theophylline. The dosage and administration of Theophylline varies according to the size and breed of the pet being treated, and the type and severity of their illness, but typically, the drug is taken every 6, 8, 12, or 24 hours The treatment groups were low-dose theophylline (n=791) or placebo (n=787), and treatment lasted for 1 year. The study was powered to detect a clinically meaningful reduction of 15% in exacerbations, but the trial found that the rate of exacerbations was actually similar in both groups, with a mean of 2·24 exacerbations with theophylline. Thus we used the synthetic biology approach to create theophylline controllable RNAi-based genetic switches which silenced TINCR in a dosage-dependent manner. Both RNAi-OFF and ON switches can be. Theophylline (dimethylxanthine) has been used to treat airway diseases for more than 80 years. It was originally used as a bronchodilator, but the relatively high doses required are associated with frequent side effects, so its use declined as inhaled β 2-agonists became more widely used.More recently it has been shown to have antiinflammatory effects in asthma and chronic obstructive.

NDC 16571-011 Theophylline(anhydrous) Theophylline

Theophylline: MedlinePlus Drug Informatio

Administration of the median theophylline dose required to achieve a therapeutic serum theophylline concentration in a given population may result in either sub-therapeutic or potentially toxic serum theophylline concentrations in individual patients. For example, at a dose of 900 mg/d in adults <60 years or 22 mg/kg/d in children 1 to 9 years. This chapter is concerned with how laboratory measurement of drug concentration in blood helps in determining correct drug dose. Such an approach is either unnecessary or unsuitable for most drug therapies, but for a limited number of drugs including lithium, digoxin and theophylline, measurement of serum or plasma concentration is the preferred method of optimising dosage and preventing.

Theophylline: Dosage, Mechanism/Onset of Action, Half-Life

  1. istration of the median theophylline dose required to achieve a therapeutic serum theophylline concentration in a given population may result in either sub-therapeutic or potentially toxic serum theophylline concentrations in individual patients. For example, at a dose of 900 mg/d in adults <60 years or 22 mg/kg/d in children 1-9 years.
  2. e and caffeine, and is readily found in nature, being present in tea.
  3. .8mg/kg/hr as maintenance dose. Schedule of Theophylline N/A Storage Requirements for Theophylline Store it at room temperature and away from excess heat and moisture. Effects of Missed Dosage of Theophylline Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule
  4. Theophylline Side Effects Common side effects of theophylline may include vomiting, headaches, nausea, and insomnia. This eMedTV article explains that while most side effects are easily treated, certain side effects (such as seizures) should be reported to a doctor

Theophylline is used to treat lung diseases such as asthma and COPD (bronchitis, emphysema).It must be used regularly to prevent wheezing and shortness of breath.This medication belongs to a class of drugs known as xanthines. It works in the airways by relaxing muscles, opening breathing passages, and decreasing the lungs' response to irritants. Controlling symptoms of breathing problems can. Monitor drug levels closely in heavy smokers. Cigarette smoking induces hepatic microsomal enzyme activity, decreasing serum half-life and increasing body clearance of theophylline. An increase of dosage from 50-100% is usual in heavy smokers For oral theophylline, the British National Formulary [1] states that serum concentrations should be measured five days after starting therapy, and at least three days after each dose adjustment. Once a maintenance dose is established, theophylline levels can be monitored every 6-12 months [2] Theophylline Drug Handout. Home » Drug Handouts » Theophylline. What is Theophylline? Theophylline is a medication closely related to caffeine. It relaxes the muscles in the airways (bronchodilator), increases the strength of the muscles involved with breathing, and improves how well mucus and debris are removed from the lungs

Theophylline is a drug that can be used for treating both cardiac and respiratory disorders in cats. If you decide to use this medication as a treatment for your asthmatic cat, you will first have to go to a veterinarian, as Theophylline can only be purchased with a prescription.. Effects of Theophylline. Cats suffering from asthma will have their condition improved in more than one way Theophylline is a bronchodilator that is used to treat symptoms of asthma, bronchitis, emphysema, and other breathing problems. Theophylline may also be used for purposes not listed in this.

This dose of theophylline was designed to produce mean serum theophylline concentrations of 7.5 mg/L; 4 volunteers received theophylline plus placebo. Pharmacokinetic parameters of theophylline were determined before grepafloxacin treatment and on day 10 of grepafloxacin or placebo administration The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is. Side effects when using theophylline include vomiting, central nervous system excitement, fever, rash and palpitations. Side effects usually subside with dosage adjustments and/or continued therapy. Theophylline should not be used in patients allergic to this class of medication. Do not use in pregnant or lactating animals Therapeutic drug monitoring. In most individuals, a plasma-theophylline concentration of 10-20 mg/litre (55-110 micromol/litre) is required for satisfactory bronchodilation, although a lower plasma-theophylline concentration of 5-15 mg/litre may be effective. Adverse effects can occur within the range 10-20 mg/litre and both the.

Theophylline: Uses, Side Effects, Dosages, Precaution

Theophylline is a bronchodilator, which a veterinarian may prescribe for your pooch to help relax her airways. While the drug may help her breathe easier, it can cause her to become nervous and restless, increase her heart rate or cause an abnormal heart rhythm, warns VeterinaryPartner.com SIDE EFFECTS. The negative side effects of theophylline include: restlessness or caffeine-type jitters (this can be minimized by starting the medication at a lower dose and gradually increasing to the recommended dose), diuretic effect (some individuals only), upset stomach, racing heart rate with abnormal heart rhythm (also only some individuals) Find information on Theophylline (Elixophyllin, Theo-24) in Davis's Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF Serum theophylline levels should be maintained at less than 10 mcg/ml in neonates and less than 20 mcg/ml in older infants. After loading dose of 1 mg/kg P.O. or I.V. for each 2 mcg/ml increase in theophylline level, infants ages 8 weeks to 6 months receive 1 to 3 mg/kg q 6 hours. Infants ages 4 to 8 weeks receive 1 to 2 mg/kg q 8 hours The analysis for drug effect showed that theophylline administration resulted in a statistically significant adverse effect on arousals per sleep hour (19.3 vs 15.9 for placebo, p = .006) and total sleep time (370.9 min vs 399.45 min for placebo, p = .015). Comparing the sum of ranks data, theophylline was found to have a significant adverse.

Theolair (Theophylline): Uses, Dosage, Side Effects

How to use Theophylline (Bulk) Powder. Consult your pharmacist or physician. Consult your pharmacist or physician. Call your doctor for medical advice about side effects. You may report side. Quick facts about Theophylline. Drug class: Respiratory. Generic status: Lower-cost generic available (theophylline) Used for. Asthma Chronic obstructive pulmonary disease Exercise-induced asthma; Prophylaxis Nocturnal asthma. Apnea in the newborn; Adjunct Nocturnal asthma. Dosage forms. Pill. Extended release Theophylline in the treatment of asthma and COPD. Theophylline has been widely used to treat asthma and COPD since the 1930s, but while effective, it is a drug having a narrow therapeutic window and also many drug-drug interactions. 1 Although the use of theophylline preparations is still defined in the Global Initiative for Asthma (GINA) 2015 report as add-on therapy for the treatment of.

Theophylline For Dogs Dose My Pe

Theophylline is usually taken twice a day, although some doctors may prescribe just one dose a day. Take the tablets/capsules exactly as your doctor tells you to. For twice daily doses, always try to take your doses 12 hours apart and at the same times each day Theophylline is a prescription medication used to treat asthma and chronic obstructive pulmonary disease ().It is part of a group of medications called methylxanthines or xanthine derivatives. Theophylline overdose effects will vary depending on a number of factors, including how much theophylline is taken and whether it is taken with any other medicines, alcohol, street drugs, or a.

Theophylline Oral Solution - FDA prescribing informationMSTC Paramedic Program / AminophyllineCounseling Parameters for Theophylline | MediMoon

The theophylline dosage was increased to 200 mg b.i.d. on day 9, and theophylline monotherapy continued through day 12. The mean apparent theophylline clearance decreased by approximately 50% during enoxacin coadministration. No significant differences in mean theophylline maximum concentration in serum, time to maximum concentration in serum. A calculator used to determine the appropriate dosage of Theophylline. Please or register first to view this content. Login Registe Theophylline belongs to a group of medicines known as bronchodilators. Bronchodilators are medicines that relax the muscles in the bronchial tubes (air passages) of the lungs. They relieve cough, wheezing, shortness of breath, and troubled breathing by increasing the flow of air through the bronchial tubes. This medicine is available only with. However, children younger than 1 year of age are more likely to have serious side effects, which may require caution and an adjustment in the dose for patients receiving theophylline. Geriatric . Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of theophylline in the elderly WARNING: Monitor results of serum theophylline level determinations carefully, and reduce dosage if serum levels exceed therapeutic range of 10-15 mcg/mL. Monitor carefully for clinical signs of adverse effects, particularly if serum theophylline levels are not available Learn about theophylline, potential side effects, proper use and dosing, and popular alternatives. Read reviews from GoodRx users who have taken theophylline and find the latest news on the drug