Difference between three types of wound healing

When a wound has closed properly, our work is done. Given the fundamental nature of wound closure, it is worth spending a few moments recapping what we know about the subject. Primary Wound Closure - Wound closure happens in one of three ways. Primary wound closure is the fastest type of closure- is also known as healing by primary intention Cutaneous wound healing is the process by which the skin repairs itself after damage. It is important in restoring normal function to the tissue. There are two main types of healing, primary intention and secondary intention. In both types, there are four stages which occur; haemostasis, inflammation, proliferation, and remodelling The human adult wound healing process can be divided into 3 or 4 distinct phases. Earlier authors referred to 3 phases—inflammatory, fibroblastic, and maturation, [ 2] which has also been denoted..

Depending on the healing time of a wound, it can be classified as acute or chronic. Those classified as acute wounds heal uneventfully (with no complications) in the predicted amount of time. Those classified as chronic wounds take a longer time to heal and might have some complications. Wounds can be open or closed Wound healing is the process whereby the skin repairs itself after injury. Wound healing can be divided into four overlapping processes; maintenance of homoeostasis, an inflammatory response, a proliferative phase, and remodeling. Maintenance of homoeostasis is achieved by clotting in any damaged regions of the circulatory system

Wound treatment is different in everybody and often depends on a number of factors. Age and skin type are two things that change how you treat a wound and avoid infection. Other factors depend on the type of wound, location, severity, and more. Avoiding infection is essential, but wound treatment does much more than that By the WoundSource Editors Promoting the wound healing process is a primary responsibility for most health care practitioners. It can take 1-3 days for a closed wound to actually establish a seal. Infections usually occur in 3-6 days but may not appear for up to 30 days, according to the CDC guidelines for preventing surgical infections. The wound healing process can be seen as an overlapping.

Three Types of Wound Closure WoundEducators

Wound healing is classically divided into hemostasis, inflammation, proliferation, and remodeling.Although a useful construct, this model employs considerable overlapping among individual phases. A complementary model has recently been described where the many elements of wound healing are more clearly delineated. The importance of this new model becomes more apparent through its utility in. Fracture healing and wound healing. 1. Fracture healing and wound healing Dr shermil sayd KMCT dental college. 2. Types of Bone • Lamellar Bone • Woven Bone or immature bone (non-lamellar) 3. Fracture • Fracture is defined as a break in the continuity of bone • Fracture results in loss of its mechanical stability and also partial. The main difference between repair and regeneration is that repair is the restoration of tissue architecture and function after an injury whereas regeneration is a type of healing in which new growth completely restores portions of damaged tissue to their normal state.. Repair and regeneration are two types of processes initiated after a tissue injury, reconstructing the damage 1) Phagocytosis of bacteria and tissue debris 2) Major source of cytokines during early inflammation 3) Release collagenases which participate in matrix and ground substance degradation during early wound healing What is second population of cells to invade a wound The complexity of the wound-healing process, which involves many cell types locally at the site of the wound as well as systemically (Fig. 2), along with comorbidities represent hurdles in identifying therapeutic targets and in clinical trial design. An added difficulty for this field of research is the paucity of animal models that precisely.

Types of chronic wounds Any acute wound (eg skin tear, surgical incision) can become chronic if the person has risk factors that impact on wound healing. However there are several types of wounds that account for the majority of chronic wounds The key difference between epithelialization and granulation is that epithelialization is a part of wound healing which forms a new epithelial surface on the open wound while granulation is the process of forming new connective tissue and blood vessels during wound healing.. Epithelialization and granulation are two processes linked to wound healing. Epithelialization covers ruptured.

Wound Healing - Primary Intention - Secondary Intention

  1. Physicians can perform three different types of wound debridement and coders will find different codes for each type. Gloria Miller, CPC, CPMA, and John David Rosdeutscher, MD, discuss the different types of debridement, as well as coding and documentation requirements
  2. It should also be noted that there is a difference between incisional wounds and excisional wounds. Incisional wounds are created when skin, muscle, and fat are incised to repair a body part. Excisional wounds occur when a cyst or other type of tissue is removed. Although these two types of wounds are very similar, there is a difference in.
  3. What is a wound? A wound is defined as a physical injury where the skin or mucous membrane is torn, pierced, cut, or otherwise broken. The process of wound healing is complex and involves inflammatory, vascular, connective tissue and epithelial cells working together over some time. To better understand wound healing, we need to learn more about the different types of wounds and factors.

Wound Healing and Repair: Overview, Types of Wound Healing

Infection of the chronic wound how to decide

From stitches to staples, tapes to glues, we're familiar with the many different types of wound closure. However, there are also three types of healing that physicians and surgeons can employ based upon the type of wound they are dealing with, whether it's an abrasion, laceration, puncture, incision, or worse A large amount of epithelial tissue present often denotes that a wound is healing successfully. When your wound is being assessed by clinicians, they will often discuss the different types of tissue that are present at the wound site. However, these technical terms are ones that are rarely, if ever, used in daily conversation Assessing and Measuring Wounds This is important because— •Each type of wound has a different etiology. •Treatment may be very different. However— •Not all wounds are clear cut. •The cause may be multifactoral. Please use the following prompts to guide your analysis, and use evidence from the literature to support your answers. 1.Distinguish between the main types of healing: first-intention and second-intention. 2.Discuss at least three factors that can delay wound healing, and identify some strategies to improve wound healing. 3.Explain the four. Although there are many types of wounds, most undergo similar stages in healing. There are 3 major stages of wound healing after a full-thickness skin wound. The duration of each stage varies with wound type, management, and the individual's overall health

Wound healing happens in several stages. Your wound may look red, swollen, and watery at the beginning. This can be a normal part of healing. The wound may have a red or pink raised scar once it. These wounds should be showing signs of healing within 2 weeks of injury. If a wound is taking longer than a couple of weeks to show signs of healing or the wound is weeping and getting larger, then this might be a sign of an underlying problem which needs looking into Wound care clinicians need to know about the different types of exudate - and how much is present - for successful wound treatment and healing. Ooze. Pus. Secretion. The drainage that seeps out of wounds can be called many things, but as wound care clinicians know, the technical term is exudate. This liquid, which is produced by the body in.

Different Types of Wounds - WoundCareCenters

Chronic wounds are the acute wounds that are healing at a slower rate or the wounds which heal only partially. The main types of wounds are classified into two types. Open wounds; Closed wounds; Open Wounds. Open wounds are the ones which have an exposed body surface at the base of the wound. There are various types of open wounds Wound healing is an important physiological process to maintain the integrity of skin after trauma, either by accident or by intent procedure. The normal wound healing involves three successive but overlapping phases, including hemostasis/inflammatory phase, proliferative phase, and remodeling phase. Aberration of wound healing, such as excessive wound healing (hypertrophic scar and keloid) or. Skin integrity and wound healing are compromised in the client who takes blood pressure medications because antihypertensives: 1) Can cause cellular toxicity. 2) Increase the risk of ischemia. 3) Delay wound healing. 4) Predispose to hematoma formation Table 4.2 Types of Wounds; Type Additional Information Surgical: Healing occurs by primary, secondary, or tertiary intention. Primary intention is where the edges are sutured or stapled closed, and the wound heals quickly with minimal tissue loss. The healing time for a surgical wound is usually short, depending on the surgery There is no significant difference in healing between the two methods. • We recommend applying the modified method of negative pressure therapy. Abstract. Background. Negative pressure therapy plays an important role in the healing process of different types of wounds. Aim of the study: this study aimed to compare between modified and.

Wound Healing Boundless Anatomy and Physiolog

  1. Secondary healing If the wound healing course in this wound is disrupted by infection, dehiscence, hypoxia or immune dysfunction, secondary healing stage begins. During secondary healing, granulation tissue formation and epithelization over this new tissue take place. These type of wounds are more susceptible to infections and poor healing
  2. Choosing the best type of collagen for you can be broken down into two simple steps: Step 1: Identify Your Specific Health Goals To maintain skin elasticity and hydration and for healthy eyes, bones, and wound healing: Try 1-2 servings daily of Marine Collagen, which is high in type 1 collagen or Bovine Collagen for high amounts of both types 1.
  3. g a biopsy to sample the cells in the wound would help us understand the differences between these wounds, says Dr. South But biopsy in these patients is extremely painful and could delay healing of the wound even further
  4. Experimental work of the last two decades has revealed the general steps of the wound healing process. This complex network has been organized in three sequential and overlapping steps. The first step of the inflammatory phase is an immediate response to injury; primary sensory neurons sense injury and send danger signals to the brain, to stop bleeding and start inflammation
  5. ECM, which is associated with deOver 20 different types of colla-gen have been identified in humans; the main types are type I, II, and III; and together they make up 80% of the body's collagen. Type I and III are important for wound healing. Role of Collagen in Wound Healing In a healing wound, a cascade of events occurs and is broken into.
  6. At Valley Wound Care Specialists, we believe that knowledge and understanding different types of wounds is central to being an informed patient. Rest assured, if you have a wound or a question regarding wounds, we are here for you. Our practice is dedicated to effectively heal all wounds from your head to toe
  7. Wounds fall into two broad categories: open or closed. In a closed wound, tissue damage and bleeding occur under the surface of the skin. Examples of closed wounds include bruises

Wound Care and Post-Op Healing Strategies. The nature of minimally invasive surgery (MIS) is both a blessing and a curse; while patients have faster recovery and less scarring, they are not available to nursing staff 24/7 for follow-up. The fact that they aren't convalescing in the hospital means there may be little follow-up to assess the. Wound dressings that create and maintain a moist environment, however, are now considered to provide the optimal conditions for wound healing. Use the resources below to learn more about the various types of wound dressings. Please note: the website you have selected is an external site hosted on a different server This knowledge of rapid wound healing has markedly advanced the understanding of delayed chronic wound healing. Lack of FOXM1 is Key to Delayed Healing The scientists sought to uncover what goes wrong in chronic wound healing by studying three different types of healing: injuries in the mouth (fast healing), skin injuries (average healing), and. The difference in healing for the ASC-treated wounds vs rhEGF-treated wounds was found to be statistically significant, and the enhancement of wound closure was confirmed via cross-sectional OCT images identifying both single layer and differentiated layers of epidermis. the ability of allogeneic human ASC to promote re-epithelialization

Beta-glucans, which existed in the cell walls of cereals, bacteria, and fungi, comprise a group of β-d-glucose polysaccharides. We investigated the effects of four kinds of beta-glucan, that are derived from barley, yeast, mushroom, and euglena on wound healing. The migration and viability of keratinocyte or fibroblast were analyzed using the in vitro scratch wound healing assay, invasion. Puncture - A deep wound caused by a sharp, stabbing object (i.e. a nail). May appear small from the outside but may damage deep tissues. Particularly dangerous on the chest, abdomen or head where major organs are at risk. Avulsion - A wound caused by a tearing force in which tissue is torn away from its normal position

There are a few things you can do to boost your immune system and aid in wound healing. Eat a healthy diet. Diet has a direct influence on blood sugar levels, so maintaining proper nutrition is key Epidermal wounds often resolve quickly and have fewer potential issues than deeper wounds. Epidermal wound healing refers to the repair of the epidermis in response to wounding. Epidermal only wounds are typically less severe than those affecting the dermis and so stages of the wound healing response may be missed Stages of wound healing. It is important to recognise that different parts of the wound can be at different stages in the wound healing process (Figure 1). This will usually be due to one part being stuck in the inflammatory phase and this is the most common reason for the formation of exuberant granulation tissue A dressing is a sterile pad or compress applied to a wound to promote healing and protect the wound from further harm. A dressing is designed to be in direct contact with the wound, as distinguished from a bandage, which is most often used to hold a dressing in place.Many modern dressings are self-adhesive

Types of Wound Dressings - Byram Healthcar

A team of researchers observe the progress of wound healing in patients. To record the stages of healing, rating scales are used, with a set of criteria to assess various aspects of wounds. The results of different researchers assessing the same set of patients are compared, and there is a strong correlation between all sets of results, so the. Two other studies detected no significant difference between the two dressing types in terms of pain on dressing removal and overall wound-related pain, but the former did reveal a slight, but not statistically significant, trend in favour of the foam dressing . Patients were asked to score on a scale of 1 to 4 (where 1 = very painful and 4. Differences between fetal and adult wound healing can be noted as early as the inflammatory stage. As previously described, adult wounds are characterized by an influx of neutrophils (299, 354) and macrophages, which secrete cytokines such as CSF-1, TNF-α, and PDGF, promoting a fibrotic response The structural properties of biomaterials play crucial roles in guiding cell behavior and influencing immune responses against the material. We fabricated electrospun membranes with three types of surface topography (random, aligned, and latticed), introduced them to dorsal skin excisional wounds in mice and rats, and evaluated their effects on wound healing and immunomodulatory properties

for wound healing are found in other processes involving dynamic tissue changes, such as development and tumor growth. Three key cellular mechanisms are necessary for wound healing: • Cellular migration • Extracellular matrix organization and remodeling • Cell proliferation Migration of Cells Initiates Repair Cells That Migrate to the Wound Although many previous studies reported that honey promotes wound healing, no study has examined the effects of Japanese honey. The aim of this study was to investigate the effects of three types of Japanese honey, Acacia, Buckwheat flour, and Chinese milk vetch honey, on wound healing in comparison with hydrocolloid dressing. Circular full-thickness skin wounds were produced on male mice The printed constructs were transparent and supported coculture of HaCaT and HSF cells to generate dermal and epidermal layers in the developed artificial skin, suitable for wound healing applications (Fig. 3-III,IV) . Sericin is also used in the dissolved form, where it is mixed with the ointment and applied on wounds Types of skin conditions characterized by pus on or just beneath the skin's surface include: Acne: Pores clogged with oil and debris form pimples or pustules on the skin's surface that contain pus. Boils or furuncles: Painful nodular bumps from infected hair follicles that are typically caused by Staphylococcus aureus

This includes a body organ or a space between organs. Signs and symptoms of surgical site infections. Any SSI may cause redness, delayed healing, fever, pain, tenderness, warmth, or swelling. These are the other signs and symptoms for specific types of SSI: A superficial incisional SSI may produce pus from the wound site A chronic wound that develops into a malignancy is referred to as a Marjolin's ulcer. 19 The incidence varies, but it is estimated that approximately 2% of chronic wounds undergo malignant transformation. 18 Marjolin's ulcer is most commonly associated with burn wounds, but has been reported in various other types of chronic, non-healing. Yet one more received a slightly different type of gauze. Every three days, the researchers measured how much healing had occurred. Dressings made from chitin with 71 percent of acetylated glucose worked best of all. That was especially easy to see on days three and six. The difference was smaller but still noticeable after 12 days Wound healing should be monitored closely, even with the use of Aquacel dressings For further savings, check out Saveritemedical, where you can find multiple options of Aquacel dressings available. The right dressing can make all the difference when dressing any type of wound that you have Similarities between tumors and healing wounds include fibroblast recruitment and activation, extracellular matrix (ECM) component deposition, infiltration of immune cells, neovascularization, and cellular lineage plasticity. However, unlike a wound that heals, the edges of a tumor are constantly expanding

No statistically significant between-group differences were detected for any comparison, for any healing outcome. Meta-analysis was feasible for one comparison (alginate and hydrocolloid dressings), with data from two RCTs (84 participants) pooled for complete healing at six weeks: risk ratio 0.42 (95% confidence interval 0.14 to 1.21) The main difference between collagen 1 2 and 3 is that collagen 1 is most abundant in bones, tendons, ligaments, and in the skin while collagen 2 occurs in hyaline and articular cartilages and collagen 3 is the main component of reticular fibers which make a supporting mesh in soft tissues and organs. Furthermore, collagen 1 is good for strong nails and hair, while collagen 2 supports joint. Types of Scars. Scars may develop anywhere on the body and can vary largely depending on their composition. They have different types, including: 1. Keloid scars. Excessive collagen production, which continues even after wound healing, leads to tissue overgrowth above skin level and is known as keloid scars Wounds may be caused either internal or external agents, resulting to different kinds of wounds such as ulcers, cuts, grazes, bruises, punctures, and burns. These wounds can either be healed by the two most commonly used wound healing methods: the primary and the secondary intention wound healing During Phase 2, a type of white blood cells called neutrophils enter the wound to destroy bacteria and remove debris. These cells often reach their peak population between 24 and 48 hours after injury, reducing greatly in number after three days

The human body is constructed from a variety of tissue types, each of which heals at a different rate and responds differently to various exercises or activities. It is important to know what type of tissue is compromised when injury occurs, in order to appropriately estimate a time frame for healing and to set appropriate expectations for. Whether wounds are closed by primary intention, subject to delayed primary closure or left to heal by secondary intention 1, the wound healing process is a dynamic one which can be divided into three phases.It is critical to remember that wound healing is not linear and often wounds can progress both forwards and back through the phases depending upon intrinsic and extrinsic forces at work.

The Wound Healing Process WoundSourc

Wound is an injury or damage to a living tissue arising from different agents. There are different types of wounds caused by different agents with various degrees of severity. Some wounds are minor but others may be severe enough to cause loss of function of a whole organ, tissue or cell. Causes of Wounds (Agents of Tissue injury) Mechanical agent This type of wound dressing is perfect for wounds on limbs or on the head, as well as wounds that are difficult to dress. 3. Non-Adherent Pads. Type of wound used for: Wounds with light to moderate drainage; works well for acute wounds and skin tears. This type of wound dressing protects wounds without sticking to the wound itself Wounds generally go through three stages as they repair (but remember, wound healing is not linear and wounds can progress both forwards and backwards through the phases on the road back to health). During the Inflammatory Phase the body produces a natural response (inflammation) to the injury and forms a clot to stop the bleeding Granulation tissue can be noted from the healthy wound buds that protrude from the wound base. During wound healing, granulation tissue usually appears during the proliferative phase. Angiogenesis is the process by which new blood vessels form, bringing in tiny capilarry buds that appear as granular tissue These three types of sutures are not the only kinds that can be used to close a wound. There are many other types of sutures, such as continuous locking sutures and purse string sutures. In general though, a great many of other sutures are simply different variations of others, such as the pulley suture being a variation of the mattress suture

They can absorb only limited amounts of wound exudate so may need to be changed every two to three days or even more frequently during early wound healing when exudation is greatest. Foam dressings are ideally suited for superficial and dry wounds eg after ablative resurfacing procedures and chronic ulcers since they provide padding that can. A wound is an injury to living tissue caused by a cut, blow, or other impacts, typically one in which the skin is cut or broken. Once wound occurs body tries to repair the defect and the process of wound healing is a summation of a number of processes which follow injury including coagulation, inflammation, matrix synthesis and deposition, angiogenesis, fibroplasia, epithelialization. 1. Introduction. The care of acute and chronic wound is the biggest challenges worldwide [].There are different kind of wounds, among them burns remain a major public health problem in developing countries [].There are different ways to heal the wound such as nano dressing [], negative pressure [], medicinal plants [], synthetic polymers [], gene therapy [], stem cell [], growth factors [] and.

Video: 7 Types Of Wound Dressings & When To Use Eac

Amount of Wound Drainage . While the type of drainage is important, the amount of drainage may be more important, depending upon the type. For example, if there is a small amount of bleeding from a wound, it may not be alarming, but blood gushing from a wound, known as a hemorrhage, is a life-threatening condition Tremendous advancements have been made in understanding the processes of wound healing. The cell types and the order in which they appear in the wound have been established; many growth factors and their functions have been elucidated. [] Despite the advances in understanding the science of wound healing, many more steps have yet to be discovered and elucidated During Stage 1 your body stops the bleeding. During Stage 2 your body fills in the gap between the two sides of the wound with Type 1 tissue. During Stage 3 the Type 1 tissue is replaced by Type 2 tissue. This makes the wound smaller. During Stage 4 your original tissue type replaces the Type 2 tissue and your wound is considered healed

Types of Exudate From Wounds Healthfull

Various categories of wound healing have been described. However, a distinction must be made between primary and secondary healing. Primary wound healing or healing by first intention (Fig 4.1-2a-c) occurs within hours after closing of a surgical incision where wound edges are directly approximated without significan Wound Healing . Wound healing is the process by which the skin, or any injured organ, repairs itself after injury. The main aim of wound healing is to prevent or limit further damage, to clean and seal the wound against infection, to restore tissue strength, and, if possible, tissue function Remodeling is the final stage of wound healing. During this period, the newly laid collagen fibers and fibroblasts reorganize along lines of tension. Fibers in a nonfunctional orientation are replaced by functional fibers. This process allows wound strength to continue to increase slowly over a long period (as long as 2 years)

-Approximate wound margins -Enhance tissue healing •Early role of suture -Wounds do not gain strength until 4-6 days after injury -Approximating of tissues depending on suture strength •The relationship between gradual loss of suture strength and slow increase of wound strength must be considere Key Differences. A type of ointment that plays a vital role in the treatment of minor injuries, dry lips or skin, etc. is known as Aquaphor. Whereas the type of ointment that used as a lubricant, moisturizer, and post-injury application to prevent the wound against bacteria and infections, etc. is known as Vaseline. There is no other name for.

Wound healing process recruits three different phases: inflammation, proliferation, and maturation. Due to the different types of wounds, as well as the advancement in medical technology, various products have been developed to repair dif-ferent skin lesions. Our objective is to investigate the advancement in wound dressings from traditional. Interestingly, the process is not linear because wounds can progress forwards and back through different phases and that usually depends upon a number of intrinsic and extrinsic factors at play. 4 Stages of Wound Healing Process. You will have to make use of different types of wound care products in order to deal with different types of wounds

Comparison between two different protocols of negative

Ulcers are defined as abnormal breaks in the skin or mucous membranes. This long-lasting sore or wound is typically characterized as slow-healing or non-healing when it has taken more than 5 to 6 weeks to heal. Although leg ulcers can develop anywhere on the leg or foot, they usually develop on the inside of the calf, just above the ankle The field of wound healing has been crying out for a better understanding of what drives a chronic wound, says Dr. South. The two different types of nanofiber dressings, described in. The use of skin grafts is a traditional technique to promote the healing of acute and chronic wounds. There are different types of skin graft.. Depending on the origin:. Autograft or autologous graft: skin obtained from the patient's own donor site.; Allograft or heterologous graft: skin obtained from another person; Xenograft or heterograft: skin from other species, such as pigs Being able to sample the wounds is a key to understanding the mechanisms behind healing. Performing a biopsy to sample the cells in the wound would help us understand the differences between. In addition, the observed similarities between the cell movements that occur during dorsal closure in D. melanogaster embryos and the healing of mammalian skin wounds, together with the.

Understanding the Healing Stages of Wounds - Advanced Tissu

In vitro wound-healing assay also known as the scratch assay. The wound-healing assay, also known as the scratch assay, is an established two-dimensional (2D) technique that can be used to investigate collective migration and wound healing in vitro [1], [2]. This method was one of the first to be developed for the study of cell migration and measures the rate at which cells, in a cell. The differences in the wound healing between the different oral soft tissues (alveolar mucosa, buccal gingiva and palatal tissue) has not been studied from a biomolecular point of view; however, differences in the clinical behavior and response between these three oral tissues has been reported It is uncertain if there is a difference in risk of wound infection between NPWT 75 mmHg and standard care (RR 0.44, 95% CI 0.17 to 1.10; 463 participants) and uncertain if there is a difference in risk of wound infection between NPWT 75 mmHg and 125 mmHg (RR 1.04, 95% CI 0.31 to 3.51; 251 participants

Types Of Wound Drainage And How To Tell When It Is Seriou

Summary. Wounds are a break in the skin and/or a disruption of the skin's normal barrier function. Wound healing is a step-wise cellular response involving fibroblasts, macrophages, endothelial cells, and keratinocytes that restore the structural and functional integrity of the skin.The four general stages of wound healing are exudative, resorptive, proliferative, and maturation There was a significant reduction in post-operative pain in the calcium alginate and bupivacaine group (group 3) at 24 and 48h when compared to the other two groups (p < 0.04). There was no difference in ease of removal of dressings or the quality of wound healing on day 10 between the three groups

Wound healing - Wikipedi

A skin graft is a piece of healthy skin removed from one area of your body to repair damaged or missing skin somewhere else on your body. This skin does not have its own source of blood flow. Learning how to care for skin flaps and grafts can help them heal more quickly and reduce scarring Individual differences of mink, including color type, are speculated to affect the course of wound healing, thereby impacting wound assessment and management on the farms, as well as the assessment of wounds in forensic cases. In this study, we examined the effect of color type on early wound healing in farmed mink. Full thickness excisional wounds (2 × 2 cm) were made on the back in 18 mink.

Difference Between Fibronectin and Laminin | FibronectinA to z of wound care

No statistically significant difference was found between groups for the EHI index for all evaluations (Mann-Whitney, P >0.05), whereas a statistically significant improvement in wound healing with time within each group was found (Friedman, P <0.05). Immediate bleeding was observed in four subjects from the SG and three from the nSG VLU is the most widely researched type of wound; thus, we compared the cost effectiveness differences between patients with VLU and patients with non-VLU wounds in the healing group. Regarding healing rates, 63/72 (87.50%) patients with VLU and 56/87 (64.37%) patients with non-VLU were in the healing group For decades, a variety of electrical stimulation (ES) types have been used to promote wound healing [1-3]. Possible mechanisms that may account for enhanced wound healing include bactericidal and bacteriostatic effects [4-6], increased blood flow [7], orientation of new collagen formation [8], and retardation of edema buildup [9] The wound healing rate and removing necrotic tissues was not significantly different between the two groups at the end of the first week of study (p=0.103). The results of study showed significant differences in wound healing rate and reduction of necrotic tissues between two groups at the second and third weeks after intervention A large review of studies 3 on honey in wound healing, particularly in burns, found that honey was more efficacious for wound healing than silver (measured in the number of days needed for wounds to heal) and less harmful to the surrounding normal skin. Manuka honey has also been shown to reduce wound swelling and pus drainage from wounds. Despite 1 trial favored laser therapy at 2 months (MD -2.55, 95 % CI: -3.87 to -1.23), the CIs did not include important differences between groups at 3 and 13 months. The function assessment showed an improvement favoring the placebo group at 1 month (MD 9.19, 95 % CI: -16.16 to -2.23) and non-significant difference between groups at 3 and 13.